Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes. |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1024565 |
| landingPage: |
http://www.iedb.org/assay/2009339 |
| type: |
Literature
|
| publicationVenue: |
PLoS One
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Influenza A virus |
| fullName: |
Nicola Clementi
Donata De Marco
Nicasio Mancini
Laura Solforosi
Guisella J Moreno
Larisa V Gubareva
Vasiliy Mishin
Andrea Di Pietro
Elisa Vicenzi
Antonio G Siccardi
Massimo Clementi
Roberto Burioni
|
| method: |
biological activity
|
| name: |
A human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes.
|
| description: |
The epitope-specific mAb PN-SIA28 was shown to broadly neutralize group 1 and 2 isolates. Residues critical for binding were identified from sequencing escape mutants. Alanine substitution analysis confirmed loss of antibody binding following residue substitution.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |