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Title: In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells.
identifier: 2012324
description:
epitope description:SNLQHIRRDVRP
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 23469060
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1026750
landingPage: http://www.iedb.org/assay/2012324
type:
Literature
publicationVenue:
PLoS One
dates:
2013
study type: b cell assays
subject species:
fullName:
Caterina Bason
Renata Lorini
Claudio Lunardi
Marzia Dolcino
Alessandro Giannattasio
Giuseppe d'Annunzio
Antonella Rigo
Nicoletta Pedemonte
Roberto Corrocher
Antonio Puccetti
method:
immunoprecipitation
name:
In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells.
description:
Affinity-purified Ab to the epitope was used to immunoprecipitate beta islet cell lysate, and a band corresponding to phogrin was seen. Binding to the protein was also seen on human beta cells.

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