High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection.

Title:

High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection.

identifier:	2012837
description:	epitope description:W101, G106, F108 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:751B11, 751B12, 750D7
aggregation:	instance of dataset
availability:	available
primaryPublications:	24027331

study type:	b cell assays
subject species:	Dengue virus

fullName:	Wen-Yang Tsai Chih-Yun Lai Yi-Chieh Wu Hong-En Lin Carolyn Edwards Amonrat Jumnainsong Srisakul Kliks Scott Halstead Juthathip Mongkolsapaya Gavin R Screaton Wei-Kung Wang

method:	biological activity

name:	High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection.
description:	The epitope-specific mAbs neutralized the virus. The neutralization potency of each MAb was determined by the concentration that gave 50% inhibition in a focus reduction neutralization test (FRNT50 value). These mAbs which were derived from secondary DENV infection showed similar inhibition both pre-attachment and post-attachment, suggesting that at least part of their neutralization was at the post-attachment step.

name:	iedb
homePage:	http://www.iedb.org

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