Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. |
| identifier: | 2012888 |
| description: |
epitope description:K96, E101, L121, E277, N278, T280, N281, N282, A283, K284, T285, S365, G366, G367, D368, I371, M420, W421, G423, G425, T449, R450, D451, G452, G453, N455, N456, R463, G466, G467, N468, K470
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:VRC-PG04
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21835983 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026961 |
| landingPage: |
http://www.iedb.org/assay/2012888 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus 1 |
| fullName: |
Xueling Wu
Tongqing Zhou
Jiang Zhu
Baoshan Zhang
Ivelin Georgiev
Charlene Wang
Xuejun Chen
Nancy S Longo
Mark Louder
Krisha McKee
Sijy O'Dell
Stephen Perfetto
Stephen D Schmidt
Wei Shi
Lan Wu
Yongping Yang
Zhi-Yong Yang
Zhongjia Yang
Zhenhai Zhang
Mattia Bonsignori
John A Crump
Saidi H Kapiga
Noel E Sam
Barton F Haynes
Melissa Simek
Dennis R Burton
Wayne C Koff
Nicole A Doria-Rose
Mark Connors
NISC Comparative Sequencing Program
James C Mullikin
Gary J Nabel
Mario Roederer
Lawrence Shapiro
Peter D Kwong
John R Mascola
|
| method: |
x-ray crystallography
|
| name: |
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
|
| description: |
Epitope residue G124 is a residue that replaced the deleted V1/V2 loop in gp120 and so does not have a corresponding residue in the natural sequence.
The epitope of VRC-PG04 Fab on the HIV-1 gp120 core from recombinant clade A/E 93TH057 was determined from the crystal structure of the complex, solved by molecular replacement. The HIV-1 gp120 core contains truncations in the variable V1/V2 and V3 loops as well as the N- and C-termini.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |