Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2018916 |
| description: |
epitope description:L32, W36, K64, Y65, Y84, L85, P86, W87, R108, P110, R111, G112, Q113, R116, Q122
antigen name:Glucagon receptor
host organism:Mus musculus Xenomouse
antibody name:mAb1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
24189067 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1027011 |
| landingPage: |
http://www.iedb.org/assay/2018916 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Susmith Mukund
Yonglei Shang
Holly J Clarke
Azadeh Madjidi
Jacob E Corn
Lance Kates
Ganesh Kolumam
Vicky Chiang
Elizabeth Luis
Jeremy Murray
Yingnan Zhang
Isidro Hö
tzel
Christopher M Koth
Bernard B Allan
|
| method: |
flow cytometry
|
| name: |
Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor.
|
| description: |
The epitope residues were calculated from [PDB: 4LF3] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope-specific mAb1 bound to wild glucagon receptor (GCGR) and GCGR with mutation G40S, expressed in 293 cells.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
