Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope.

Title:

Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope.

Dataset

identifier:	2018928
description:	epitope description:NFFRMVISNPAAT antigen name:Glutamate decarboxylase 2 host organism:Homo sapiens antibody name:G1H12
aggregation:	instance of dataset
availability:	available
primaryPublications:	24090977

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1027025
landingPage:	http://www.iedb.org/assay/2018928

Publication

type:	Literature
publicationVenue:	J Autoimmun
dates:	2013

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Rony Dahan John A Gebe Anton Preisinger Eddie A James Mark Tendler Gerald T Nepom Yoram Reiter

Data Type

method:	flow cytometry

Study

name:	Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope.
description:	The epitope-specific mAb bound the epitope in complex with the HLA-DR molecule (ELISA and ICS). Moreover, the mAb was able to recognize the epitope expressed on Preiss cells. Recognition of the epitope/HLA-DR complexes was demonstrated in vitro, as well as ex vivo on GAD-transfected cells.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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