Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2019188 |
| description: |
epitope description:A32, G33, Y36, Q37, W39, E40, R43, Q47, F65, M67, Y68, Y87, P89, W90, R113, H115, E119
antigen name:Gastric inhibitory polypeptide receptor
host organism:Homo sapiens
antibody name:Gipg013
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
23689510 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1026308 |
| landingPage: |
http://www.iedb.org/assay/2019188 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Peter Ravn
Chaithanya Madhurantakam
Susan Kunze
Evelyn Matthews
Claire Priest
Siobhan O'Brien
Andie Collinson
Monika Papworth
Maria Fritsch-Fredin
Lutz Jermutus
Lambertus Benthem
Markus Gruetter
Ronald H Jackson
|
| method: |
biological activity
|
| name: |
Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor.
|
| description: |
Epitope residues were calculated from [PDB: 4HJO] as the antigen residues at 4 Å
atomic distance from the antibody.
The epitope-specific antibody Gipg013 cross-reacts with the rat GIP receptor and inhibits its function. Inhibition was demonstrated by Gipg013 antagonism of GIP-stimulated cAMP production in GIPr-overexpressing HEK293 cells; IC50 = 19 nM. Antibody Gipg013 also inhibited the GIP-enhanced glucose-stimulated insulin secretion in isolated rat pancreatic islet cells.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
