Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2019377 |
| description: |
epitope description:I422, T425, L427, N428, C429, N430, E431, S432, L433, N434, G436, L438, A439, L441, F442, Y443, Q444, H445, K446, P505, S528, W529, A531, Y613
antigen name:Genome polyprotein
host organism:Homo sapiens
antibody name:AR3C
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
24288331 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1027028 |
| landingPage: |
http://www.iedb.org/assay/2019377 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2013
|
| study type: | b cell assays |
| subject species: | Hepatitis C virus (isolate H77) |
| fullName: |
Leopold Kong
Erick Giang
Travis Nieusma
Rameshwar U Kadam
Kristin E Cogburn
Yuanzi Hua
Xiaoping Dai
Robyn L Stanfield
Dennis R Burton
Andrew B Ward
Ian A Wilson
Mansun Law
|
| method: |
x-ray crystallography
|
| name: |
Hepatitis C virus E2 envelope glycoprotein core structure.
|
| description: |
The epitope of AR3C Fab on a soluble E2 construct was determined from the crystal structure of the complex, solved by molecular replacement. There are two complexes in the asymmetric unit. The engineered E2c had truncations at the N and C termini, substitution of the potentially flexible variable region 2 (VR2, residues 400-485) with a Gly-Ser-Ser-Gly linker, and mutations N448D and N576D to remove glycosylation sites.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
