Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms.

Title:

Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms.

Dataset

identifier:	2020845
description:	epitope description:PDSRESLAWQTAT antigen name:Genome polyprotein host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	24131712

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1027066
landingPage:	http://www.iedb.org/assay/2020845

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2014

Dimension

study type:	b cell assays
subject species:	Enterovirus A71

Person

fullName:	Xiaohua Ye Zhiqiang Ku Qingwei Liu Xiaoli Wang Jinping Shi Yunfang Zhang Liangliang Kong Yao Cong Zhong Huang

Data Type

method:	in vivo assay

Study

name:	Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms.
description:	The epitope sequence was deduced. The epitope-specific antiserum protected the mice from virus challenge. Survival and clinical signs were measured. In an additional experiment, BALB/c mice born to dams immunized with the epitope were challenged with the virus. Fifteen of 16 immunized (93.8%) mice were protected from severe disease and death, only showing transient and minor symptoms at 8 and 9 dpi.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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