MER5101, a novel Abeta1-15:DT conjugate vaccine, generates a robust anti-Abeta antibody response and attenuates Abeta pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.

Title:

MER5101, a novel Abeta1-15:DT conjugate vaccine, generates a robust anti-Abeta antibody response and attenuates Abeta pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.

Dataset

identifier:	2021228
description:	epitope description:DAEFRHDSGYEVHHQ antigen name:Amyloid beta A4 protein host organism:Mus musculus APPswe/PSEN1
aggregation:	instance of dataset
availability:	available
primaryPublications:	23595760

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1025752
landingPage:	http://www.iedb.org/assay/2021228

Publication

type:	Literature
publicationVenue:	J Neurosci
dates:	2013

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Bin Liu Jeffrey L Frost Jing Sun Hongjun Fu Stephen Grimes Peter Blackburn Cynthia A Lemere

Data Type

method:	ELISA

Study

name:	MER5101, a novel Abeta1-15:DT conjugate vaccine, generates a robust anti-Abeta antibody response and attenuates Abeta pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice.
description:	The epitope-based MER5101 vaccine generates high anti-amyloid beta antibody levels in plasma from immunized mice mice. IgG1 anti-amyloid antibodies were predominant followed by IgG2b antibodies. Plasma anti-amyloid beta antibodies from vaccinated mice also bound amyloid monomers and oligomers in Western blot.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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