A common solution to group 2 influenza virus neutralization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A common solution to group 2 influenza virus neutralization.

Dataset

identifier:	2021493
description:	epitope description:A: P37, E341, K342; B: E360, G361, I363, D364, R370, T377, Q379, L383 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:CR8043
aggregation:	instance of dataset
availability:	available
primaryPublications:	24335589

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1027116
landingPage:	http://www.iedb.org/assay/2021493

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2014

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Hong Kong/1/1968(H3N2))

Person

fullName:	Robert H E Friesen Peter S Lee Esther J M Stoop Ryan M B Hoffman Damian C Ekiert Gira Bhabha Wenli Yu Jarek Juraszek Wouter Koudstaal Mandy Jongeneelen Hans J W M Korse Carla Ophorst Els C M Brinkman-van der Linden Mark Throsby Mark J Kwakkenbos Arjen Q Bakker Tim Beaumont Hergen Spits Ted Kwaks Ronald Vogels Andrew B Ward Jaap Goudsmit Ian A Wilson

Data Type

method:	x-ray crystallography

Study

name:	A common solution to group 2 influenza virus neutralization.
description:	The epitope of CR8043 Fab on the 1968 pandemic H3 hemagglutinin was determined from the crystal structure of the complex. The asymmetric unit consists of an HA trimer liganded by three Fabs, which bind near the bottom of the HA stem to the conservative epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.