A common solution to group 2 influenza virus neutralization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A common solution to group 2 influenza virus neutralization.

Dataset

identifier:	2021536
description:	epitope description:A: P37, E341, K342; B: E360, G361, I363, D364, R370, T377, Q379, L383 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:CR8043
aggregation:	instance of dataset
availability:	available
primaryPublications:	24335589

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1027116
landingPage:	http://www.iedb.org/assay/2021536

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2014

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Hong Kong/1/1968(H3N2))

Person

fullName:	Robert H E Friesen Peter S Lee Esther J M Stoop Ryan M B Hoffman Damian C Ekiert Gira Bhabha Wenli Yu Jarek Juraszek Wouter Koudstaal Mandy Jongeneelen Hans J W M Korse Carla Ophorst Els C M Brinkman-van der Linden Mark Throsby Mark J Kwakkenbos Arjen Q Bakker Tim Beaumont Hergen Spits Ted Kwaks Ronald Vogels Andrew B Ward Jaap Goudsmit Ian A Wilson

Data Type

method:	bio-layer interferometry assay

Study

name:	A common solution to group 2 influenza virus neutralization.
description:	The epitope specific CR8043 Fab bound to hemmagglutin from the influenza virus. Fab CR8043 bound with high affinity to group 2 H3 and H10 HA subtypes and accommodated about 50 years of antigenic drift from avian (1963) to human (1968-2011) H3N2 viruses. CR8043 bound with lower affinity to group 2 H4, H7, H15 and H15 subtypes. KD's were determined by bio-layer interferometry using an Octet RED intsrument, which is conceptually similar to surface plasmon resonance.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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