A common solution to group 2 influenza virus neutralization. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A common solution to group 2 influenza virus neutralization.

Dataset

identifier:	2021578
description:	epitope description:A: P37, E341, K342; B: E360, G361, I363, D364, R370, T377, Q379, L383 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:CR8043
aggregation:	instance of dataset
availability:	available
primaryPublications:	24335589

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1027116
landingPage:	http://www.iedb.org/assay/2021578

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2014

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Hong Kong/1/1968(H3N2))

Person

fullName:	Robert H E Friesen Peter S Lee Esther J M Stoop Ryan M B Hoffman Damian C Ekiert Gira Bhabha Wenli Yu Jarek Juraszek Wouter Koudstaal Mandy Jongeneelen Hans J W M Korse Carla Ophorst Els C M Brinkman-van der Linden Mark Throsby Mark J Kwakkenbos Arjen Q Bakker Tim Beaumont Hergen Spits Ted Kwaks Ronald Vogels Andrew B Ward Jaap Goudsmit Ian A Wilson

Data Type

method:	bio-layer interferometry assay

Study

name:	A common solution to group 2 influenza virus neutralization.
description:	The epitope specific mAb CR8043 binds to H3 hemmagglutin and competes with mAb CR8020 for binding, as shown by bio-layer interferometry. Both mAbs are broadly neutralizing antibodies obtained from the same donor but are derived from different germ-line genes. They recognize overlapping epitopes on the HA stem.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.