Regulatory roles for NKT cell ligands in environmentally induced autoimmunity. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.

Dataset

identifier:	2022117
description:	epitope description:1-O-(6-acetamido-6-deoxy-alpha-D-galactosyl)-N-[(15Z)-tetracos-15-enoyl]phytosphingosine host organism:Mus musculus A.SW
aggregation:	instance of dataset
availability:	available
primaryPublications:	18981095

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026087
landingPage:	http://www.iedb.org/assay/2022117

Publication

type:	Literature
publicationVenue:	J Immunol
dates:	2008

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Jaya Vas Jochen Mattner Stewart Richardson Rachel Ndonye John P Gaughan Amy Howell Marc Monestier

Data Type

method:	in vivo assay

Study

name:	Regulatory roles for NKT cell ligands in environmentally induced autoimmunity.
description:	Injection of the epitope along with HgCl2 increased the susceptibility to mercury-induced autoimmunity, as shown by enhanced production of IgE anti-nucleolar autoantibodies. Injection of the epitope on day -7, in conjunction with a low dose of HgCl2, prevented the establishment of tolerance as assayed by the production of IgG1, IgG2a and IgE anti-nucleolar autoantibodies.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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