Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1027085 |
| landingPage: |
http://www.iedb.org/assay/2023152 |
| type: |
Literature
|
| publicationVenue: |
Neurobiol Dis
|
| dates: |
2014
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Marybeth Camboni
Chiou-Miin Wang
Carlos Miranda
Jung Hae Yoon
Rui Xu
Deborah Zygmunt
Brian K Kaspar
Paul T Martin
|
| method: |
western blot
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| name: |
Active and passive immunization strategies based on the SDPM1 peptide demonstrate pre-clinical efficacy in the APPswePSEN1dE9 mouse model for Alzheimer's disease.
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| description: |
The epitope-specific mAb recognized purified A beta 1–40 and A beta 1–42 from brain of APP/PS mice expressing human amyloid beta. Brain peptide levels were reduced by 50% or more in young or old APP/PS mice immunized with the SDPM1-4E peptide (EEEEAECDWGKGGRWRLWPGASGKTEACGP) compared to mock-immunized APP/PS animals.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
