Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2114135 |
| description: |
epitope description:V410, L412, A414, Q415, R416, L418, C419, H434, C435, D437, G438, L439, Y475, V477, S478, E479, G480, D483, E527, K528, D554, Y555, D572, A573, C574, K575, S578, S597, W598, G599, E600, G601, C602, R604, G609
antigen name:Plasma kallikrein
host organism:Homo sapiens
antibody name:DX-2930
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
24970892 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1027977 |
| landingPage: |
http://www.iedb.org/assay/2114135 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2014
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jon A Kenniston
Ryan R Faucette
Diana Martik
Stephen R Comeau
Allison P Lindberg
Kris J Kopacz
Gregory P Conley
Jie Chen
Malini Viswanathan
Niksa Kastrapeli
Janja Cosic
Shauna Mason
Mike DiLeo
Jan Abendroth
Petr Kuzmic
Robert C Ladner
Thomas E Edwards
Christopher TenHoor
Burt A Adelman
Andrew E Nixon
Daniel J Sexton
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| method: |
biological activity
|
| name: |
Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
|
| description: |
The epitope residues were calculated from [PDB: 4OGX and 4OGY] as the antigen residues at 4Å
atomic distance from the antibody. Contacts residues V410, A414 and Q415 are only in structure [PDB: 4OGX] and contact residue L439 is only in [PDB: 4OGY].
The epitope-specific antibody DX-2930 inhibited the catalytic activity of pKal in vitro. DX-2930 inhibits both free and high molecular weight kininogen (HMWK)-bound pKal.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
