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Title: Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.
identifier: 2110991
description:
epitope description:Y2009, Y2018, E2021, N2031, T2032, E2033, D2034, G2035, F2036
antigen name:Toxin B
host organism:Mus musculus HuMAb (Medarex)
antibody name:Bezlotoxumab
aggregation:
instance of dataset
availability:
available
primaryPublications: 24821719
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1027969
landingPage: http://www.iedb.org/assay/2110991
type:
Literature
publicationVenue:
J Biol Chem
dates:
2014
study type: b cell assays
subject species: Clostridium difficile VPI 10463
fullName:
Peter Orth
Li Xiao
Lorraine D Hernandez
Paul Reichert
Payal R Sheth
Maribel Beaumont
Xiaoyu Yang
Nicholas Murgolo
Grigori Ermakov
Edward DiNunzio
Fred Racine
Jerzy Karczewski
Susan Secore
Richard N Ingram
Todd Mayhood
Corey Strickland
Alex G Therien
method:
surface plasmon resonance (SPR)
name:
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.
description:
The epitope-specific mAb bound to the toxin as measured at the high affinity binding site by SPR.

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