Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2111076 |
| description: |
epitope description:alpha-L-Rhap-(1->2)-alpha-L-Rhap-(1->3)-[alpha-D-Glcp-(1->4)]-alpha-L-Rhap-(1->3)-beta-D-GlcpNAc-(1->2)-alpha-L-Rhap3Ac-(1->2)-alpha-L-Rhap-(1->3)-[alpha-D-Glcp-(1->4)]-alpha-L-Rhap-(1->3)-beta-D-GlcpNAc,OCH2CH2NH2
antigen name:lipopolysaccharide
host organism:Mus musculus BALB/c
antibody name:F22-4
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
24836582 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1027877 |
| landingPage: |
http://www.iedb.org/assay/2111076 |
| type: |
Literature
|
| publicationVenue: |
Org Biomol Chem
|
| dates: |
2014
|
| study type: | b cell assays |
| subject species: | Shigella flexneri 2a |
| fullName: |
Charles Gauthier
Pierre Chassagne
Franç
ois-Xavier Theillet
Catherine Guerreiro
oise Thouron
Farida Nato
Muriel Delepierre
Philippe J Sansonetti
Armelle Phalipon
Laurence A Mulard
|
| method: |
antigen inhibition (~ IC50)
|
| name: |
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity.
|
| description: |
The epitoipe inhibited the binding of the mAb F22-4 to Shigella flexneri 2a LPS. The epitope did not significantly inhibit the binding of SF2a-specific protective mAbs A2-1 (IgG2a), D15-7 (IgG1), C1-7 (IgG3) or E4-7 (IgG2b). The authors conclude that while the 6D′-acetate has no major influence on Ab recognition, the 3A-O-acetyl group displays a striking mIgG-specific effect on Ab binding. Only mAb F22-4 is able to recognize diversely O-acetylated segments of the SF2a O-Ag chain. None of the two acetates present on the SF2a O-Ag adds significantly to broad Ab recognition.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
