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Title: Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution.
identifier: 2113032
description:
epitope description:L506, T512
antigen name:spike glycoprotein [Human betacoronavirus 2c EMC/2012]
host organism:Homo sapiens
antibody name:3B12-Fc
aggregation:
instance of dataset
availability:
available
primaryPublications: 24778221
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1027643
landingPage: http://www.iedb.org/assay/2113032
type:
Literature
publicationVenue:
Proc Natl Acad Sci U S A
dates:
2014
study type: b cell assays
subject species: Human betacoronavirus 2c EMC/2012
fullName:
Xian-Chun Tang
Sudhakar S Agnihothram
Yongjun Jiao
Jeremy Stanhope
Rachel L Graham
Eric C Peterson
Yuval Avnir
Aimee St Clair Tallarico
Jared Sheehan
Quan Zhu
Ralph S Baric
Wayne A Marasco
method:
antigen inhibition
name:
Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution.
description:
The epitope-specific scFvFc was isolated by biopanning with S1 protein expressing 293T cells. The construct also blocked S protein or S-VLP binding to hDPP4-expressing cells.

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