Dengue virus envelope domain III immunization elicits predominantly cross-reactive, poorly neutralizing antibodies localized to the AB loop: implications for dengue vaccine design.

Title:

Dengue virus envelope domain III immunization elicits predominantly cross-reactive, poorly neutralizing antibodies localized to the AB loop: implications for dengue vaccine design.

Dataset

identifier:	2119273
description:	epitope description:Q316, H317 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:3D3, 5A1, 5A12, 5C30, 5E7, 3B8, 2C49, 2E14, 3A3
aggregation:	instance of dataset
availability:	available
primaryPublications:	23851440

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026825
landingPage:	http://www.iedb.org/assay/2119273

Publication

type:	Literature
publicationVenue:	J Gen Virol
dates:	2013

Dimension

study type:	b cell assays
subject species:	Dengue virus 2

Person

fullName:	Xiao-Quan Li Li-Wen Qiu Yue Chen Kun Wen Jian-Piao Cai Jing Chen Yu-Xian Pan Jie Li Dong-Mei Hu Yan-Fen Huang Li-Dong Liu Xi-Xia Ding Yong-hui Guo Xiao-Yan Che

Data Type

method:	biological activity

Study

name:	Dengue virus envelope domain III immunization elicits predominantly cross-reactive, poorly neutralizing antibodies localized to the AB loop: implications for dengue vaccine design.
description:	Neutralization assays using an ELISPOT-based micro-neutralization test (ELISPOT-MNT) demonstrated the neutralizing activities of the epitope-specific mAbs against infection of LLC-MK2 cells with the virus.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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