Identification of a free core B-cell epitope in the lipopolysaccharide of <i>Francisella tularensis</i> | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification of a free core B-cell epitope in the lipopolysaccharide of Francisella tularensis

Dataset

identifier:	2117122
description:	epitope description:alpha-D-GalNAc-(1->2)-beta-D-Man-(1->4)-[beta-D-Glc-(1->2)]-alpha-D-Man-(1->5)-alpha-Kdo antigen name:lipopolysaccharide host organism:Mus musculus BALB/c antibody name:Ab66
aggregation:	instance of dataset
availability:	available

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1028059
landingPage:	http://www.iedb.org/assay/2117122

Publication

type:	Submission
dates:	2014

Dimension

study type:	b cell assays
subject species:	Francisella tularensis subsp. holarctica LVS

Person

fullName:	Zhaohua Lu Ph.D. Guillermo Madico M.D.-Ph.D. Qi Wang Ph.D. Joseph Zaia Ph.D. Catherine E. Costello Ph.D. Jacqueline Sharon Ph.D.

Data Type

method:	cross blocking

Study

name:	Identification of a free core B-cell epitope in the lipopolysaccharide of Francisella tularensis
description:	The epitope is composed of HexNAcHex3Kdo, which is one type of core structure of F. tularensis LPS. It can be found in Wang et al., Biochemistry 2011, 50:10941-50 [PMID:22091710]. The core epitope specific mAb Ab65 inhibited the binding of Ab66 to LPS from F. tularensis holactica strain LVS, indicating that the two antibodies recognize the same or overlapping epitopes. Ab66 also inhibited the binding of Ab65 to LPS.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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