Identification of a free core B-cell epitope in the lipopolysaccharide of <i>Francisella tularensis</i> | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification of a free core B-cell epitope in the lipopolysaccharide of Francisella tularensis

Dataset

identifier:	2117114
description:	epitope description:alpha-D-GalNAc-(1->2)-beta-D-Man-(1->4)-[beta-D-Glc-(1->2)]-alpha-D-Man-(1->5)-alpha-Kdo antigen name:lipopolysaccharide host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1028059
landingPage:	http://www.iedb.org/assay/2117114

Publication

type:	Submission
dates:	2014

Dimension

study type:	b cell assays
subject species:	Francisella tularensis subsp. holarctica LVS

Person

fullName:	Zhaohua Lu Ph.D. Guillermo Madico M.D.-Ph.D. Qi Wang Ph.D. Joseph Zaia Ph.D. Catherine E. Costello Ph.D. Jacqueline Sharon Ph.D.

Data Type

method:	in vivo assay

Study

name:	Identification of a free core B-cell epitope in the lipopolysaccharide of Francisella tularensis
description:	The epitope is composed of HexNAcHex3Kdo, which is one type of core structure of F. tularensis LPS. It can be found in Wang et al., Biochemistry 2011, 50:10941-50 [PMID:22091710]. The epitope-specifc monoclonal antibody Ab65 did not reduce the blood bacterial burden determined 3 days after infection with F. tularensis Schu S4.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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