Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.

Title:

Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.

identifier:	2117461
description:	epitope description:E25, N27, A28, S29, Q31, T32, K33, D35, S58, A59, D60, A61, D62, K125, K127, S153 antigen name:Protein L1 host organism:Mus musculus BALB/c antibody name:M12B9
aggregation:	instance of dataset
availability:	available
primaryPublications:	25031354

study type:	b cell assays
subject species:	Vaccinia virus WR

fullName:	Thomas Kaever Xiangzhi Meng Michael H Matho Andrew Schlossman Sheng Li Inbal Sela-Culang Yanay Ofran Mark Buller Ryan W Crump Scott Parker April Frazier Shane Crotty Dirk M Zajonc Bjoern Peters Yan Xiang

method:	x-ray crystallography

name:	Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.
description:	The epitope of M12B9 Fab on L1 was determined from the crystal structure of the complex, solved by molecular replacement. Four copies of the Fab/L1 complex were present in the asymmetric unit.

name:	iedb
homePage:	http://www.iedb.org

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