NK T cells provide lipid antigen-specific cognate help for B cells. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

NK T cells provide lipid antigen-specific cognate help for B cells.

Dataset

identifier:	2118155
description:	epitope description:nitrophenol host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	18550809

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026250
landingPage:	http://www.iedb.org/assay/2118155

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2008

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Elizabeth A Leadbetter Manfred Brigl Petr Illarionov Nadia Cohen Megan C Luteran Shiv Pillai Gurdyal S Besra Michael B Brenner

Data Type

method:	ELISA

Study

name:	NK T cells provide lipid antigen-specific cognate help for B cells.
description:	Immunization with NP-alphaGalCer stimulated higher titers of anti-NIP IgG and IgM than immunization with NP-KLH in wild type C57BL/6 mice. Immunization of CD1d-/- and Jalpha18-/- mice with NP-alphaGalCer did not stimulate an anti-NIP response, indicating the requirement for iNKT cells. CD4 was not required for a response. Immunization with NP-alphaGalCer preferentially induces IgM, IgG2c and IgG3 anti-NIP. Immunization with NP-KLH stimulated preferentially IgG1 and IgG2b anti-NIP titers.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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