Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 2118924 |
| description: |
epitope description:E238, P249, T250, L260, D261, R263, C264, V265, E266, T267, C268, P269, P270, P271, Y272, H274, N308, N309
antigen name:Insulin receptor
host organism:Mus musculus BALB/c
antibody name:83-7
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
25092300 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1028109 |
| landingPage: |
http://www.iedb.org/assay/2118924 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2014
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
John G Menting
Yanwu Yang
Shu Jin Chan
Nelson B Phillips
Brian J Smith
Jonathan Whittaker
Nalinda P Wickramasinghe
Linda J Whittaker
Vijay Pandyarajan
Zhu-li Wan
Satya P Yadav
Julie M Carroll
Natalie Strokes
Charles T Roberts Jr
Faramarz Ismail-Beigi
Wieslawa Milewski
Donald F Steiner
Virander S Chauhan
Colin W Ward
Michael A Weiss
Michael C Lawrence
|
| method: |
x-ray crystallography
|
| name: |
Protective hinge in insulin opens to enable its receptor engagement.
|
| description: |
The epitope residues were calculated from [PDB: 4OGA] as the antigen residues at 4Å
atomic distance from the antibody.
The epitope of Fab 83-7 on the insulin receptor ectodomain was determined from the crystal structure of the quaternary complex of the insulin receptor L1-CR construct IR310.T, human insulin AB chains, the insulin receptor alphaCT(704-719) peptide and Fab 83-7 (""Complex A""). Fab 83-7 binds to insulin receptor at the CR (cysteine-rich) domain.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
