Definition and characterization of novel HLA-*A02-restricted CD8+ T cell epitopes derived from JCV polyomavirus with clinical relevance.

Title:

Definition and characterization of novel HLA-*A02-restricted CD8+ T cell epitopes derived from JCV polyomavirus with clinical relevance.

identifier:	3113463
description:	epitope description:SLMNVHSNG antigen name:Human polyomavirus 2 protein host organism:Homo sapiens mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	27705933

study type:	t cell assays
subject species:	JC polyomavirus

fullName:	Jiju Mani Lei Wang Angela G Hü ckelhoven Anita Schmitt Alma Gedvilaite Nan Jin Christian Kleist Anthony D Ho Michael Schmitt

method:	ICS

name:	Definition and characterization of novel HLA-*A02-restricted CD8+ T cell epitopes derived from JCV polyomavirus with clinical relevance.
description:	MLPC assays were performed for one week. Afterwards restimulation was performed for six hours in the presence of Brefeldin A followed by intracellular cytokine staining. In all tested donors, predominantly the effector memory T cell (TEM) sub-population, CD45RA- (antigen sensitized T cells) and CCR7- (memory population), secreted type-1 cytokines.

name:	iedb
homePage:	http://www.iedb.org

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