Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 3133692 |
| description: |
epitope description:LQLQPFPQPQLPYPQPQLPYPQPQLPYPQPQPF + DEAM(Q10, 17, 24)
antigen name:Other Triticum aestivum (Canadian hard winter wheat) protein
host organism:Homo sapiens
t cell receptor:TCC364.1.0.14
mhc allele name:HLA-DQA1*05:01/DQB1*02:01
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22366952 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1031389 |
| landingPage: |
http://www.iedb.org/assay/3133692 |
| type: |
Literature
|
| publicationVenue: |
Nat Med
|
| dates: |
2012
|
| study type: | t cell assays |
| subject species: | Triticum aestivum |
| fullName: |
Roberto Di Niro
Luka Mesin
Nai-Ying Zheng
Jorunn Stamnaes
Michael Morrissey
Jane-Hwei Lee
Min Huang
Rasmus Iversen
M Fleur du Pré
Shuo-Wang Qiao
Knut E A Lundin
Patrick C Wilson
Ludvig M Sollid
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| method: |
ELISA
|
| name: |
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.
|
| description: |
Epitope (DQ2.5-glia-alpha2)-specific T cells responded to the epitope presented by A20 cells transfected with DQ2.5 or by A20-DQ2.5-IgD cells, as measured by murine IL-2 release. A20-DQ2.5-IgD are cells expressing both HLA-DQ2.5 and the TG2-binding IgD 679-14-E06. The cells also responded to A20-DQ2.5-IgD cells loaded with preformed complexes of TG2 with non-deamidated 33mer, which becomes deamidated during complex formation. This indicates a role for the TG2-specific BCR in internalization and processing of the complexes for presentation and recognition by T cells.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
