Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors.

Title:

Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors.

identifier:	3138009
description:	epitope description:KLVALGINAV antigen name:Genome polyprotein host organism:Homo sapiens t cell receptor:HAT-140pM mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	27902325

study type:	t cell assays
subject species:	Hepatitis C virus

fullName:	Huajun Zhang Jianbing Zhang Lei Chen Zhiming Weng Ye Tian Haifeng Zhao Youjia Li Lin Chen Zhaoduan Liang Hongjun Zheng Wenzhuo Zhao Shi Zhong Yi Li

method:	binding assay

name:	Targeting naturally occurring epitope variants of hepatitis C virus with high-affinity T-cell receptors.
description:	In order to improve the affinity of the HCV-specific TCR, phage display libraries containing degenerated complementarity-determining regions of the TCR alpha and ß chains were constructed. Soluble TCR heterodimer was produced by in vitro refolding and purification, and injected through BIAcore chips captured with biotinylated pHLA using multi-cycle kinetics on BIAcore T200.

name:	iedb
homePage:	http://www.iedb.org

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