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Title: Identification of Zika Virus Epitopes Reveals Immunodominant and Protective Roles for Dengue Cross-Reactive CD8+ T cells in Mice
identifier: 3137688
description:
epitope description:RPALLVSFIF
antigen name:Zika virus protein
host organism:Mus musculus IFNR null
mhc allele name:HLA-B*07:02
aggregation:
instance of dataset
availability:
available
primaryPublications: 28288094
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1031207
landingPage: http://www.iedb.org/assay/3137688
type:
Dual
dates:
2017
study type: t cell assays
subject species: Zika virus
fullName:
Jinsheng Wen Ph.D.
William Weihao Tang Mr.
Nicholas Sheets Mr.
Julia Ellison Ms
Kenneth Kim Mr.
Sujan Shresta Ph.D.
method:
ICS
name:
Identification of Zika Virus Epitopes Reveals Immunodominant and Protective Roles for Dengue Cross-Reactive CD8+ T cells in Mice
description:
Mice were immunized with a cocktail of 3 HLA-B*0702 ZIKV immunodominant epitopes and then challenged with ZIKV. Epitope-specific cytokines responses were then assessed. In a separate experiment, anti-CD8 abs were used to deplete CD8+ T cells from immunized mice. Depletion of CD8s caused majority of epitope-specific responses to be absent.

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