Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Title:

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

identifier:	3198098
description:	epitope description:SIINFEKL antigen name:Gal d 2 host organism:Mus musculus OT-1 TCR Tg mhc allele name:H2-Kb
aggregation:	instance of dataset
availability:	available
primaryPublications:	28270614

study type:	t cell assays
subject species:	Gallus gallus

fullName:	Novalia Pishesha Angelina M Bilate Marsha C Wibowo Nai-Jia Huang Zeyang Li Rhogerry Dhesycka Djenet Bousbaine Hojun Li Heide C Patterson Stephanie K Dougan Takeshi Maruyama Harvey F Lodish Hidde L Ploegh

method:	in vivo assay

name:	Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
description:	In mice that received epitope-RBC, the transferred T cells showed only modest expansion, compared with mice receiving an equivalent number of unmodified RBCs or epitope peptide. Upon in vitro restimulation with epitope, the T cells produced fewer proinflammatory cytokines, TNF-alpha, and IFN-gamma, than OT-I T cells from mice that received OT-I peptide alone. These cells also failed to respond to ovalbumin. These cells displayed characteristics of nonresponsive (tolerant) cells. The epitope was synthesized with GGGK(biotin)KKFR on the N-terminus.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.