Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.

Title:

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.

identifier:	3369559
description:	epitope description:LLYGFVNYV host organism:Homo sapiens t cell receptor:A6 mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	21282516

study type:	t cell assays
subject species:

fullName:	Oleg Y Borbulevych Kurt H Piepenbrink Brian M Baker

method:	surface plasmon resonance (SPR)

name:	Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.
description:	The affinity of the WT-peptide-reactive A6 TCR bound to the complex of modified epitope/HLA-A2 was determined. Substitution G2L and I9V at anchor positions 2 and 9 in the epitope increased the affinity of A6 TCR for the peptide/ MHC complex.

name:	iedb
homePage:	http://www.iedb.org

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