An allosteric site in the T-cell receptor Cbeta domain plays a critical signalling role. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

An allosteric site in the T-cell receptor Cbeta domain plays a critical signalling role.

Dataset

identifier:	3350973
description:	epitope description:RGPGRAFVTI antigen name:Envelope glycoprotein gp160 host organism:Mus musculus BALB/c t cell receptor:B4.2.3 mhc allele name:H2-Db
aggregation:	instance of dataset
availability:	available
primaryPublications:	28508865

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1031827
landingPage:	http://www.iedb.org/assay/3350973

Publication

type:	Literature
publicationVenue:	Nat Commun
dates:	2017

Dimension

study type:	t cell assays
subject species:	HIV-1 M:B_HXB2R

Person

fullName:	Kannan Natarajan Andrew C McShan Jiansheng Jiang Vlad K Kumirov Rui Wang Huaying Zhao Peter Schuck Mulualem E Tilahun Lisa F Boyd Jinfa Ying Ad Bax David H Margulies Nikolaos G Sgourakis

Data Type

method:	ELISA

Study

name:	An allosteric site in the T-cell receptor Cbeta domain plays a critical signalling role.
description:	A T cell hybridoma expressing the B4.2.3 TCR responded to the epitope presented by A20 B cells. Mutation S127A, N133AA or K134A in the TCR ß chain near the H3 helix reduced the response, but did not affect the dissociation rate of B4.2.3 TCR with the epitope/H-2Db complex.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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