Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy.

Title:

Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy.

Dataset

identifier:	3364111
description:	epitope description:MTENLTVQPERLGVL antigen name:ESX-1 secretion-associated protein EspC host organism:Homo sapiens mhc allele name:HLA class II
aggregation:	instance of dataset
availability:	available
primaryPublications:	28588103

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1031863
landingPage:	http://www.iedb.org/assay/3364111

Publication

type:	Literature
publicationVenue:	Clin Sci (Lond)
dates:	2017

Dimension

study type:	t cell assays
subject species:	Mycobacterium tuberculosis

Person

fullName:	Jiangping Li Juan Shen Suihua Lao Xiaomin Li Jie Liu Changyou Wu

Data Type

method:	biological activity

Study

name:	Mycobacterium tuberculosis Rv3615c is a highly immunodominant antigen and specifically induces potent Th1-type immune responses in tuberculosis pleurisy.
description:	The epitope triggered the signaling cascade of activation as measured by CD3epsilon, ZAP-70, Lck, LAT, SLP-76, PLCg1, Src, p38 MAPK, pErk1/2, c-Jun, and T-bet activation.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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