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Title: Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
identifier: 3465807
description:
epitope description:FSWGAEGQRPGFG
antigen name:Myelin basic protein (UniProt:P02686)
host organism:Homo sapiens
t cell receptor:MS2-3C8
mhc allele name:HLA-DRA*01:01/DRB1*04:01
aggregation:
instance of dataset
availability:
available
primaryPublications: 21297580
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1021504
landingPage: http://www.iedb.org/assay/3465807
type:
Literature
publicationVenue:
EMBO J
dates:
2011
study type: t cell assays
subject species: Homo sapiens
fullName:
Yiyuan Yin
Yili Li
Melissa C Kerzic
Roland Martin
Roy A Mariuzza
method:
binding assay
name:
Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
description:
The epitope-specific TCR MS2-3C8 bound to immobilized HLA-DR4 with the epitope covalently linked to the N-terminus of the beta chain. Koff rate was determined by Surface plasmon resonance.

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