Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 3465809 |
| description: |
epitope description:FSWGAEGQRPGFG
antigen name:Myelin basic protein (UniProt:P02686)
host organism:Homo sapiens
t cell receptor:MS2-3C8 T29A alpha-chain mutant
mhc allele name:HLA-DRA*01:01/DRB1*04:01
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21297580 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1021504 |
| landingPage: |
http://www.iedb.org/assay/3465809 |
| type: |
Literature
|
| publicationVenue: |
EMBO J
|
| dates: |
2011
|
| study type: | t cell assays |
| subject species: | Homo sapiens |
| fullName: |
Yiyuan Yin
Yili Li
Melissa C Kerzic
Roland Martin
Roy A Mariuzza
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
|
| description: |
The epitope-specific TCR MS2-3C8 with mutated T29 residue in CDR1alpha had a 12-fold increased affinity over the WT TCR. The mutation is at position 31 in the PDB sequence.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
