Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.

Title:

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.

identifier:	3382417
description:	epitope description:LLFGYPVYV antigen name:Protein Tax-1 host organism:Homo sapiens Caucasian t cell receptor:A6c134R mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	23805144

study type:	t cell assays
subject species:	Human T-lymphotropic virus 1

fullName:	David K Cole Malkit Sami Daniel R Scott Pierre J Rizkallah Oleg Y Borbulevych Penio T Todorov Ruth K Moysey Bent K Jakobsen Jonathan M Boulter Brian M Baker Yi Li

method:	surface plasmon resonance (SPR)

name:	Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode.
description:	The affinity of the variant A6c134R TCR for binding to the epitope/HLA-A2 complex was determined by surface plasmon resonance.

name:	iedb
homePage:	http://www.iedb.org

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