A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.

Title:

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.

identifier:	3465803
description:	epitope description:ENPVVHFFKNIVTPR antigen name:Myelin basic protein (UniProt:P02686) host organism:Homo sapiens t cell receptor:Hy.1B11 alpha chain N97A mutant mhc allele name:HLA-DQ1
aggregation:	instance of dataset
availability:	available
primaryPublications:	21199956

study type:	t cell assays
subject species:	Homo sapiens

fullName:	Dhruv K Sethi David A Schubert Anne-Kathrin Anders Annie Heroux Daniel A Bonsor Chantz P Thomas Eric J Sundberg Jason Pyrdol Kai W Wucherpfennig

method:	surface plasmon resonance (SPR)

name:	A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
description:	Hy.1B11 alpha chain N97A mutant TCR bound to the epitope/HLA-DQ1 complex with intermediate affinity. The position of the N residue in the PDB sequence is 96.

name:	iedb
homePage:	http://www.iedb.org

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