HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.

Title:

HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.

identifier:	3241872
description:	epitope description:YYSKNLNSFF host organism:Homo sapiens t cell receptor:16C/114 mhc allele name:HLA-A*24:02
aggregation:	instance of dataset
availability:	available
primaryPublications:	28423700

study type:	t cell assays
subject species:

fullName:	Barbara Schrö rs Silke Lü bcke Volker Lennerz Martina Fatho Anne Bicker Catherine Wö lfel Patrick Derigs Thomas Hankeln Dirk Schadendorf Annette Paschen Thomas Wö

method:	ELISPOT

name:	HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.
description:	Autologous mixed lymphocyte-tumor cell culture responder populations were evaluated for IFNg production against the candidate neo-epitope. Critical residues (F438 for MMS22Lmut) were identified by co-transfection of HLA restricting elements along with cDNAs containing the peptide fragments.

name:	iedb
homePage:	http://www.iedb.org

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