Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Dataset

identifier:	3241983
description:	epitope description:2-hydroxy-1-naphthaldehyde host organism:Homo sapiens t cell receptor:A-F7 mhc allele name:human MR1
aggregation:	instance of dataset
availability:	available
primaryPublications:	28166217

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1031636
landingPage:	http://www.iedb.org/assay/3241983

Publication

type:	Literature
publicationVenue:	Nat Immunol
dates:	2017

Dimension

study type:	t cell assays
subject species:

Person

fullName:	Andrew N Keller Sidonia B G Eckle Weijun Xu Ligong Liu Victoria A Hughes Jeffrey Y W Mak Bronwyn S Meehan Troi Pediongco Richard W Birkinshaw Zhenjun Chen Huimeng Wang Criselle D'Souza Lars Kjer-Nielsen Nicholas A Gherardin Dale I Godfrey Lyudmila Kostenko Alexandra J Corbett Anthony W Purcell David P Fairlie James McCluskey Jamie Rossjohn

Data Type

method:	in vitro assay

Study

name:	Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
description:	The epitope inhibited the activation of Jurkat T cells expressing the MAIT A-F7, #6 or C-F7 TCR by 5-OP-RU and CIR B cells over-expressing MR1, as determined expression of the activation marker CD69.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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