Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Dataset

identifier:	3242010
description:	epitope description:N(2)-acetyl-6-formylpterin host organism:Homo sapiens mhc allele name:human MR1
aggregation:	instance of dataset
availability:	available
primaryPublications:	28166217

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1031636
landingPage:	http://www.iedb.org/assay/3242010

Publication

type:	Literature
publicationVenue:	Nat Immunol
dates:	2017

Dimension

study type:	t cell assays
subject species:

Person

fullName:	Andrew N Keller Sidonia B G Eckle Weijun Xu Ligong Liu Victoria A Hughes Jeffrey Y W Mak Bronwyn S Meehan Troi Pediongco Richard W Birkinshaw Zhenjun Chen Huimeng Wang Criselle D'Souza Lars Kjer-Nielsen Nicholas A Gherardin Dale I Godfrey Lyudmila Kostenko Alexandra J Corbett Anthony W Purcell David P Fairlie James McCluskey Jamie Rossjohn

Data Type

method:	in vitro assay

Study

name:	Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.
description:	The epitope inhibited the activation of MAIT cells by 5-OP-RU, as determined by inhibition of TNF or IFNgamma production and inhibition of proliferation.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.