An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.

Title:

An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.

Dataset

identifier:	3340352
description:	epitope description:ATEGRVRVNSAYQDK antigen name:Aggrecan core protein (UniProt:P16112) host organism:Mus musculus BALB/c mhc allele name:H2 class II
aggregation:	instance of dataset
availability:	available
primaryPublications:	28583308

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1031836
landingPage:	http://www.iedb.org/assay/3340352

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2017

Dimension

study type:	t cell assays
subject species:	Homo sapiens

Person

fullName:	Katalin Mikecz Tibor T Glant Adrienn Markovics Kenneth S Rosenthal Julia Kurko Roy E Carambula Steve Cress Harold L Steiner Rd Daniel H Zimmerman

Data Type

method:	in vivo assay

Study

name:	An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis.
description:	Vaccination of the mice with the epitope conjugated to DGQEEKAGVVSTGLIGGG (DerG-PG70), but not to DLLKNGERIEKVEGGG (J-PG70) inhibited disease progression of cartilage proteoglycan (PG)-induced arthritis (PGIA) and G1-domain-induced arthritis (GIA). Significant decreases in visual and histopathological scores of arthritis were observed.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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