Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

Title:

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

identifier:	3479215
description:	epitope description:SIYRGYYL host organism:Mus musculus BALB.B t cell receptor:m6 mhc allele name:H2-Kb
aggregation:	instance of dataset
availability:	available
primaryPublications:	18941216

study type:	t cell assays
subject species:

fullName:	Lindsay L Jones Leremy A Colf Jennifer D Stone K Christopher Garcia David M Kranz

method:	multimer/tetramer

name:	Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.
description:	The epitope, when bound to H-2Kb, was selecetd for activation of the 2C TCR. Epitope/Kb tetramers bound to CD8- T cell lines transfected with the 2C-T7 TCR, specific for QL9 peptide/Ld, but not to T cell lines transfected with m6 2C variant TCR, selected for high affinity binding to QL9/Ld.

name:	iedb
homePage:	http://www.iedb.org

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