Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

Title:

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

identifier:	3479288
description:	epitope description:AQWGPDPAAA host organism:Homo sapiens t cell receptor:1E6 mhc allele name:HLA-A*02:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	20639478

study type:	t cell assays
subject species:

fullName:	David K Cole Emily S J Edwards Katherine K Wynn Mathew Clement John J Miles Kristin Ladell Julia Ekeruche Emma Gostick Katherine J Adams Ania Skowera Mark Peakman Linda Wooldridge David A Price Andrew K Sewell

method:	cytometric bead array

name:	Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
description:	The T cell clone 1E6, derived by stimulation with the WT peptide ALWGPDPAAA, reacted more strongly to the L2Q analog than to the WT peptide.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.