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Title: T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.
identifier: 3477109
description:
epitope description:WIRVNIPKRI
host organism:Homo sapiens
t cell receptor:ANi2.3
mhc allele name:HLA-DRB3*03:01
aggregation:
instance of dataset
availability:
available
primaryPublications: 23091041
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1025226
landingPage: http://www.iedb.org/assay/3477109
type:
Literature
publicationVenue:
Proc Natl Acad Sci U S A
dates:
2012
study type: t cell assays
subject species:
fullName:
Lei Yin
Frances Crawford
Philippa Marrack
John W Kappler
Shaodong Dai
method:
binding assay
name:
T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.
description:
The epitope is a mimotope of Ni2+ presented by human HLA-DR52c bearing an unknown peptide.
The affinity of the Ni-reactive ANi2.3 TCR for the DR52c-mimotope complex produced with baculovirus was determined by surface plasmon resonance.

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