Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

Title:

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

identifier:	3477355
description:	epitope description:SIYRGYYL host organism:Mus musculus BALB.B t cell receptor:m6 mhc allele name:H2-Kb
aggregation:	instance of dataset
availability:	available
primaryPublications:	18941216

study type:	t cell assays
subject species:

fullName:	Lindsay L Jones Leremy A Colf Jennifer D Stone K Christopher Garcia David M Kranz

method:	surface plasmon resonance (SPR)

name:	Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.
description:	The epitope, when bound to H-2Kb, was selecetd for activation of the 2C TCR. The m6 2C variant scTCR, originally isolated as specific for QL9 peptide/Ld and selected for high affinity binding to QL9-Ld complex, bound to the epitope/Kb complex with similar affinity than the parent 2C-T7 scTCR (KD = 22100 nM).

name:	iedb
homePage:	http://www.iedb.org

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