Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.

Title:

Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.

identifier:	3479346
description:	epitope description:HPGSVNEFDF antigen name:Dense granule antigen (UniProt:Q19PW5) host organism:Mus musculus C57BL/6 X BALB/c mhc allele name:H2-Ld
aggregation:	instance of dataset
availability:	available
primaryPublications:	27421704

study type:	t cell assays
subject species:	Toxoplasma gondii

fullName:	H Hamlet Chu Shiao-Wei Chan John Paul Gosling Nicolas Blanchard Alexandra Tsitsiklis Grant Lythe Nilabh Shastri Carmen Molina-Parí s Ellen A Robey

method:	multimer/tetramer

name:	Continuous Effector CD8(+) T Cell Production in a Controlled Persistent Infection Is Sustained by a Proliferative Intermediate Population.
description:	The epitope sequence was published in the cited reference Blanchard et al., Nat Immunol. 2008 Aug;9(8):937-44 [PMID: 18587399]. Brain and spleen cells showed similar results. Persistent infection led to a dominant epitope specific response that was maintained as short lived Teff cells were continuously produced. Epitope specific cells became increasingly more KLRG1 high and CD62L, PD-1, Ki62, and CXCR3 low after infection. During acute resolved infection, decreasing antigen load correlated with a sharp drop in the Tint population and loss of the ongoing response.

name:	iedb
homePage:	http://www.iedb.org

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