Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.

Title:

Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.

identifier:	3479536
description:	epitope description:FEAFMARAKAAVD host organism:Mus musculus TCR transgenic t cell receptor:J809.B5 mhc allele name:H2-IAb
aggregation:	instance of dataset
availability:	available
primaryPublications:	24813203

study type:	t cell assays
subject species:

fullName:	Brian D Stadinski Peter Trenh Brian Duke Priya G Huseby Guoqi Li Lawrence J Stern Eric S Huseby

method:	surface plasmon resonance (SPR)

name:	Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.
description:	The affinity of the epitope-specific TCR for the peptide/I-Ab complex was determined by surface plasmon resonance. The parent J809.B5 TCR did not bind the peptide/I-Ab complex with significant affinity. The peptide was selected from an I-Ab random peptide baculovirus library for binding to J809.B5 alpha Y31A T cells.

name:	iedb
homePage:	http://www.iedb.org

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