Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.

Title:

Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.

identifier:	3479576
description:	epitope description:FEAQKAKANKAVD host organism:Mus musculus TCR transgenic t cell receptor:13.D5 Y31A mhc allele name:H2-IAb
aggregation:	instance of dataset
availability:	available
primaryPublications:	24813203

study type:	t cell assays
subject species:

fullName:	Brian D Stadinski Peter Trenh Brian Duke Priya G Huseby Guoqi Li Lawrence J Stern Eric S Huseby

method:	bioassay

name:	Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity.
description:	The epitope-specific 13.D5 T cell hybridoma with mutation of the residue CDR1alpha Y31A was activated with the epitope more strongly than the wild-type 13.D5 TCR.

name:	iedb
homePage:	http://www.iedb.org

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