An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.

Title:

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.

identifier:	3479585
description:	epitope description:HSRKKCDEL antigen name:Genome polyprotein host organism:Homo sapiens t cell receptor:DD31 mhc allele name:HLA-B*08:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	25355921

study type:	t cell assays
subject species:	Hepatitis C virus subtype 2b

fullName:	Usha K Nivarthi Stephanie Gras Lars Kjer-Nielsen Richard Berry Isabelle S Lucet John J Miles Samantha L Tracy Anthony W Purcell David S Bowden Margaret Hellard Jamie Rossjohn James McCluskey Mandvi Bharadwaj

method:	binding assay

name:	An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant.
description:	The binding affinity of the DD31 TCR, specific for peptide HSKKKCDEL, for the HLA-B*0801–epitope complex was determined by surface plasmon resonance.

name:	iedb
homePage:	http://www.iedb.org

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