Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.

Title:

Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.

Dataset

identifier:	3479608
description:	epitope description:LPEPLPQGQLTAY antigen name:Trans-activator protein BZLF1 host organism:Homo sapiens t cell receptor:CA5 mhc allele name:HLA-B*35:01
aggregation:	instance of dataset
availability:	available
primaryPublications:	23569211

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1026301
landingPage:	http://www.iedb.org/assay/3479608

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2013

Dimension

study type:	t cell assays
subject species:	Human gammaherpesvirus 4

Person

fullName:	Yu Chih Liu John J Miles Michelle A Neller Emma Gostick David A Price Anthony W Purcell James McCluskey Scott R Burrows Jamie Rossjohn Stephanie Gras

Data Type

method:	binding assay

Study

name:	Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.
description:	The equilibrium dissociation constant for the CA5 TCR binding to the epitope/HLA-B35:01 complex was determined by surface plasmon resonance. The CA5 TCR bound to the epitope/HLA-B35:01 complex with weaker affinity than to epitope/HLA-B*35:08.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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